Evidence supporting the use of: Magnolol
For the health condition: Insomnia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnolol, a bioactive compound derived from the bark of Magnolia officinalis, has been traditionally used in Chinese medicine for its calming effects. In recent years, preclinical studies have investigated its potential to support or treat insomnia. Animal studies suggest that magnolol exerts sedative and anxiolytic effects primarily through modulation of the GABAergic system—similar to how benzodiazepines act. For example, research published in Phytomedicine (2012) demonstrated that magnolol prolonged sleep time in mice and increased sleep duration in pentobarbital-induced sleep tests. Other studies (e.g., Journal of Ethnopharmacology, 2008) have shown magnolol enhances GABAA receptor activity, which is strongly associated with sleep induction and maintenance. However, human clinical data are extremely limited; most evidence comes from animal or in vitro models. There are no large, well-controlled clinical trials confirming its efficacy or safety for insomnia treatment in people. Thus, while magnolol's use for insomnia has a scientific basis rooted in preclinical research and mechanistic plausibility, the overall strength of evidence remains low (rated 2/5). More high-quality human studies are necessary before magnolol can be recommended as a standard therapeutic option for insomnia.

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Other ingredients used for Insomnia

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
benegut perilla (proprietary)
black cumin
Indian frankincense
rice
calcium
California poppy
cassia bark
chamomile
cherry
Chinese salvia root
cinnamon
Coptis chinensis
fennel
GABA (gamma aminobutyric acid)
gooseberry
gotu kola
greek mountain tea
heartwood
hops
jujube
kava root
kudzu
l-tryptophan
lactium casein decapeptide
lavender
maca
magnesium
magnolia
marine lipid
melatonin
moringa
motherwort
ophiopogon root
orange
passionflower
perilla
phytocannabinoids
pollen
polygala root
quail egg
reishi mushroom
rose oil
saffron
sage
scrophularia root
skullcap
valerian root
vitamin B6
zinc
catnip
tangerine
anise
blackboard tree
lingzhi
lingusticum wallichii
morus
silk tree
chrysanthemum
amber
ganoderma
lotus seed
anemarrhena asphodeloides
purslane
aster root
peach
wood betony
goji berry
soursop
Aralia
Agastache
Alpha-terpineol
Angelica
Apigenin
Anamu
Albizia
Agarwood
Anemone
Alpha lactalbumin
Agrimonia pilosa
Arani
Atractylone
Betony
Black Seed
Baikal Skullcap
Blackthorn
Balsam
Bayleaf
Big Quaking Grass
Banyan
Brahmi
Borassus Palm
Borassus aethiopum
Bupleurum
Centella triterpenes
Chinese Silkvine
Clary sage
Clerodendrum trichotomum
Cactus
Cyathula
Citron
Carry Me Seed
Cannabinol
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Capitate Valerian
Corktree
Cowslip
Cannabidiol
Calamus
Cherimoya
Corydalis
Carthamus
Clerodendrum indicum
Dragonhead
David's Milkberry
Doxylamine succinate
European Elder
Erodium cicutarium
Elk antler
Elephant's Head
Embelia
Flueggea suffruticosa
Ficus religiosa
Ficus simplicissima
Glycine
jasmine
Lotus
Lily
Little ironweed
Mallow
Milk Protein
Mimosa
Orchid
Poppy
Rose
Spikenard
Sandalwood
Sumac
Sweet Orange alcohol
Vervain
walnut

Products containing Magnolol

We currently have no products on Vitabase that contain this ingredient.