Evidence supporting the use of: Ophiopogon root
For the health condition: Insomnia

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ophiopogon root (Ophiopogon japonicus), known as Mai Men Dong in Traditional Chinese Medicine (TCM), has a long history of use in East Asian herbal medicine, particularly for nourishing yin, moistening the lungs, and calming the spirit (Shen). In TCM theory, insomnia is often attributed to underlying imbalances such as yin deficiency, and Ophiopogon root is believed to help restore this balance, thereby supporting restful sleep. Classical texts and modern TCM practitioners frequently include Mai Men Dong in formulas aimed at treating sleep disturbances, especially when accompanied by symptoms such as dry mouth, irritability, or night sweats. However, despite its widespread traditional use, scientific validation specifically for insomnia is limited. There are few modern clinical studies directly investigating the sedative or sleep-promoting effects of Ophiopogon root in humans. Some preclinical studies suggest that Ophiopogon extracts may have mild neuroprotective or stress-reducing effects, but these findings are preliminary and not specific to sleep. The majority of its reputation for treating insomnia comes from centuries of empirical use within the context of TCM rather than robust clinical trials. Therefore, while Ophiopogon root is traditionally used for insomnia, the scientific evidence to support its efficacy for this specific indication remains weak.

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Other ingredients used for Insomnia

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
benegut perilla (proprietary)
black cumin
Indian frankincense
rice
calcium
California poppy
cassia bark
chamomile
cherry
Chinese salvia root
cinnamon
Coptis chinensis
fennel
GABA (gamma aminobutyric acid)
gooseberry
gotu kola
greek mountain tea
heartwood
hops
jujube
kava
kudzu
L-tryptophan
lactium casein decapeptide
lavender
maca
magnesium
magnolia
marine lipid
melatonin
moringa
motherwort
ophiopogon root
orange
passionflower
perilla
phytocannabinoids
pollen
polygala root
quail egg
reishi mushroom
rose oil
saffron
sage
scrophularia root
skullcap
valerian root
vitamin B6
zinc
catnip
tangerine
anise
blackboard tree
lingzhi
Szechuan lovage
morus
silk tree
chrysanthemum
amber
ganoderma
lotus seed
anemarrhena asphodeloides
purslane
aster root
peach
wood betony
goji berry
soursop
Aralia
Agastache
Alpha-terpineol
Angelica
Apigenin
Anamu
Albizia
Agarwood
Anemone
Alpha lactalbumin
Agrimonia pilosa
Arani
Atractylone
Betony
Black Seed
Baikal Skullcap
Blackthorn
Balsam
Bayleaf
Big Quaking Grass
Banyan
Brahmi
Borassus Palm
Borassus aethiopum
Bupleurum
Centella triterpenes
Chinese Silkvine
Clary sage
Clerodendrum trichotomum
Cactus
Cyathula
Citron
Carry Me Seed
Cannabinol
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Capitate Valerian
Corktree
Cowslip
Cannabidiol
Calamus
Cherimoya
Corydalis
Carthamus
Clerodendrum indicum
Dragonhead
David's Milkberry
Doxylamine succinate
European Elder
Erodium cicutarium
Elk antler
Elephant's Head
Embelia
Flueggea suffruticosa
Ficus religiosa
Ficus simplicissima
Fringed Pink
Frankincense
Gelsemium
Geraniol
Giant Blazingstar
Glycine
Gardenia jasminoides
Homalomena
Honeybush
jasmine
Jatoba
Jujubosides
Jatamansi
Kavalactones
Kukicha
Kiwi
Lycium
Loquat
lemon balm
Lactucarium
Lady of the Night
Lesser speargrass
Lilium polyphyllum
Linden
Longan
Lindera
Lotus
Labrador Tea
Large-Leaved Linden
Lily
Little ironweed
Lupulinum
Loranthus
Linalool
Mesua
Myrcene
Marjoram
Mallow
Mace
Milk Protein
Matapalo Tree
Mimosa
Microtea debilis
Morning Glory
Magnolol
Mulungu
Macaranga indica
Nardostachys
Night jessamine
Nymphaea caerulea
Nymphaea nouchali
Ophiopogon
Oroxylum indicum
Onosma bracteatum
Orchid
Osmanthus
Osthole
Premna
Polysaccharides
Pulsatilla
Patchouli oil
Phlorotannins
portulaca
Passionfruit
Polygonatum
Pimpinella
Persimmon
Paeoniflorin
Poppy
Polygonum
Polygala
Rue
Rauvolfia
Rubiaceae
Rose
Rooibos
Speedwell
Scoparia dulcis
Sumbul
Self-Heal
Sweet Annie
Spikenard
Salvia
Sensitive Plant
Southernwood
Sarivan
Shankhpushpi
Sweet Woodruff
Schisandrins
Sandalwood
Semecarpus anacardium
Stachytarpheta cayennensis
Sumac
Sweet Bay
Sword Bean
Saffranal
Sedanenolide
Sweet Orange alcohol
Terminalia
Tagara
Tetrahydropalmatine
Vetiver
Valerenic acid
Vervain
Verbena
Withanolides
Wax Gourd
walnut
Winter Begonia
Winter Savory
Yuzu
Yellow-Fruit Nightshade
Ylang ylang

Products containing ophiopogon root

Metagenics Serenagen®
Metagenics Serenagen