Evidence supporting the use of: Passionflower
For the health condition: Insomnia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Passionflower (Passiflora incarnata) has a long history of traditional use for treating insomnia and anxiety, primarily in North and South American folk medicine. Scientifically, there is some evidence supporting its use for mild sleep disturbances. Several randomized controlled trials (RCTs) and animal studies suggest that passionflower extracts may have mild sedative effects, likely due to modulation of gamma-aminobutyric acid (GABA) neurotransmission in the brain, which is known to promote relaxation and sleep. For example, a small double-blind, placebo-controlled study published in 2011 found that participants who consumed passionflower tea reported modest improvements in sleep quality compared to placebo. However, the sample sizes in these studies are generally small, and the methodological quality is variable.

Systematic reviews conclude that while passionflower may be a safe natural remedy for mild insomnia, the overall quality and quantity of clinical evidence is limited, and its efficacy is less well-established compared to more thoroughly studied herbal remedies like valerian. Most clinical guidelines do not recommend passionflower as a first-line treatment for insomnia due to the limited data. In summary, passionflower's use for insomnia is supported by some scientific evidence, but the strength of evidence is currently low (rated 2/5).

More about passionflower
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Other ingredients used for Insomnia

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
benegut perilla (proprietary)
black cumin
Indian frankincense
rice
calcium
California poppy
cassia bark
chamomile
cherry
Chinese salvia root
cinnamon
Coptis chinensis
fennel
GABA (gamma aminobutyric acid)
gooseberry
gotu kola
greek mountain tea
heartwood
hops
jujube
kava root
kudzu
l-tryptophan
lactium casein decapeptide
lavender
maca
magnesium
magnolia
marine lipid
melatonin
moringa
motherwort
ophiopogon root
orange
passionflower
perilla
phytocannabinoids
pollen
polygala root
quail egg
reishi mushroom
rose oil
saffron
sage
scrophularia root
skullcap
valerian root
vitamin B6
zinc
catnip
tangerine
anise
blackboard tree
lingzhi
lingusticum wallichii
morus
silk tree
chrysanthemum
amber
ganoderma
lotus seed
anemarrhena asphodeloides
purslane
aster root
peach
wood betony
goji berry
soursop
Aralia
Agastache
Alpha-terpineol
Angelica
Apigenin
Anamu
Albizia
Agarwood
Anemone
Alpha lactalbumin
Agrimonia pilosa
Arani
Atractylone
Betony
Black Seed
Baikal Skullcap
Blackthorn
Balsam
Bayleaf
Big Quaking Grass
Banyan
Brahmi
Borassus Palm
Borassus aethiopum
Bupleurum
Centella triterpenes
Chinese Silkvine
Clary sage
Clerodendrum trichotomum
Cactus
Cyathula
Citron
Carry Me Seed
Cannabinol
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Capitate Valerian
Corktree
Cowslip
Cannabidiol
Calamus
Cherimoya
Corydalis
Carthamus
Clerodendrum indicum
Dragonhead
David's Milkberry
Doxylamine succinate
European Elder
Erodium cicutarium
Elk antler
Elephant's Head
Embelia
Glycine
jasmine
Lotus
Lily
Little ironweed
Mallow
Milk Protein
Mimosa
Orchid
Poppy
Rose
Spikenard
Sandalwood
Sumac
Sweet Orange alcohol
Vervain
walnut