Evidence supporting the use of: Phlorotannins
For the health condition: Insomnia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Phlorotannins are polyphenolic compounds derived from brown seaweeds and have recently garnered scientific interest for their potential effects on sleep. Research, particularly from South Korea, has demonstrated that phlorotannins possess sedative-hypnotic properties. Notably, several preclinical and clinical studies suggest that phlorotannins may exert their effects through modulation of the GABAA receptors, which are the same targets as many traditional hypnotic drugs such as benzodiazepines. For example, a randomized, double-blind, placebo-controlled clinical trial published in Phytotherapy Research (2018) found that supplementation with phlorotannin-rich extract from Ecklonia cava significantly improved sleep latency, total sleep time, and sleep efficiency in adults with mild to moderate insomnia compared to placebo. The study attributed these effects to the GABAergic activity of phlorotannins. Additional animal studies support the hypothesis that phlorotannins can increase non-REM and REM sleep, further corroborating their potential as sleep-promoting agents.

However, while the early evidence is promising and indicates scientific interest and initial validation, large-scale, long-term clinical trials are still lacking. The overall evidence base is moderate but not yet robust, warranting a rating of 3 on the scale. More research is needed to confirm efficacy and safety for the treatment of insomnia.

More about Phlorotannins
More about Insomnia

Other ingredients used for Insomnia

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
benegut perilla (proprietary)
black cumin
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rice
calcium
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cassia bark
chamomile
cherry
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cinnamon
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fennel
GABA (gamma aminobutyric acid)
gooseberry
gotu kola
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heartwood
hops
jujube
kava root
kudzu
l-tryptophan
lactium casein decapeptide
lavender
maca
magnesium
magnolia
marine lipid
melatonin
moringa
motherwort
ophiopogon root
orange
passionflower
perilla
phytocannabinoids
pollen
polygala root
quail egg
reishi mushroom
rose oil
saffron
sage
scrophularia root
skullcap
valerian root
vitamin B6
zinc
catnip
tangerine
anise
blackboard tree
lingzhi
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morus
silk tree
chrysanthemum
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ganoderma
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purslane
aster root
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goji berry
soursop
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Clerodendrum trichotomum
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Cannabinol
Cymbopogon Martini
Calea zacatechichi
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Products containing Phlorotannins

We currently have no products on Vitabase that contain this ingredient.