Evidence supporting the use of: 5-Hydroxytryptophan (5-HTP)
For the health condition: Irritability

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid and chemical precursor to serotonin, a neurotransmitter that plays a key role in mood regulation. There is some scientific basis for considering 5-HTP as a supplement to address mood-related symptoms, such as irritability. Several clinical studies have investigated 5-HTP for conditions like depression, anxiety, and fibromyalgia, all of which can have irritability as a symptom. By increasing serotonin levels, 5-HTP may theoretically help reduce irritability, especially when it is associated with low mood or mood disorders.

However, direct evidence supporting 5-HTP specifically for irritability is limited. Most research focuses on its effects on depression or generalized anxiety, with irritability often considered a secondary measure rather than a primary outcome. Some studies in populations with premenstrual syndrome (PMS) or certain neurological disorders have reported reductions in irritability, but these findings are not robust or consistently replicated.

Overall, while there is a plausible biological mechanism and some indirect evidence suggesting 5-HTP may help with irritability, the direct scientific evidence is weak and more research is needed. The evidence rating is 2/5, indicating limited but suggestive support. Caution is also warranted due to potential side effects and interactions, particularly serotonin syndrome if combined with other serotonergic agents.

More about 5-Hydroxytryptophan (5-HTP)
More about Irritability