Pulsatilla, also known as Pasque flower, is a remedy frequently used in traditional homeopathy and herbal medicine for emotional symptoms, including irritability, mood swings, and tearfulness. The use of Pulsatilla for irritability is based largely on traditional homeopathic principles, where it is recommended for individuals exhibiting sensitivity, mood changes, and emotional lability. In classic homeopathic practice, it is believed to be particularly suited to those who are gentle, yielding, and easily affected by external influences, with irritability being one of several emotional symptoms addressed.

However, there is a lack of robust scientific evidence supporting the effectiveness of Pulsatilla for irritability. Clinical trials and systematic reviews have not demonstrated consistent or convincing efficacy for this indication. Most available evidence is anecdotal, stemming from historical use and practitioner reports rather than controlled studies. Furthermore, Pulsatilla is often used in highly diluted forms within homeopathy, raising questions about biological plausibility from a conventional scientific perspective.

In summary, the use of Pulsatilla for irritability is justified primarily by traditional homeopathic use, with minimal empirical evidence from modern scientific studies to support its efficacy for this specific condition.