Purple Monkeyflower (Mimulus kelloggii or related Mimulus species) is most commonly associated with traditional and alternative uses, particularly within the Bach Flower Remedies system, for supporting emotional states such as irritability, fear, or anxiety. The Bach Flower Remedies, developed by Dr. Edward Bach in the 1930s, are a set of flower essences intended to address negative emotional states. "Mimulus" is one of the original remedies and is suggested for individuals experiencing known fears or irritability.

However, the evidence for efficacy in addressing irritability is primarily anecdotal and rooted in the Bach system's philosophy, which is not based on modern scientific research or clinical trials. There are no published, peer-reviewed scientific studies demonstrating that Purple Monkeyflower or its extracts have measurable effects on irritability or related symptoms in humans. The use is supported by historical and traditional accounts, including those of herbalists and practitioners of flower essence therapy, but lacks validation through rigorous scientific methods.

In summary, Purple Monkeyflower's reputation for helping with irritability is grounded in traditional use, particularly within the context of flower essence therapy, rather than scientific evidence. The overall strength of evidence supporting its use for irritability is very limited.