Evidence supporting the use of: Valerian
For the health condition: Irritability

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Valerian (Valeriana officinalis) has a long history of use in traditional herbal medicine, primarily as a remedy for insomnia, anxiety, and nervous tension. Its use for irritability is largely based on the traditional association of irritability with nervous system disturbances or restlessness, conditions for which valerian has been historically employed. Herbalists and folk medicine practitioners have recommended valerian as a calming agent, intending to soothe emotional agitation, which often overlaps with symptoms of irritability.

However, modern scientific research supporting valerian specifically for irritability is limited. Most clinical studies have focused on valerian’s effects on sleep disorders and general anxiety, rather than directly assessing its impact on irritability as a symptom or standalone condition. The presumed benefits for irritability are extrapolated from its sedative and anxiolytic properties, believed to be mediated by compounds such as valerenic acids influencing gamma-aminobutyric acid (GABA) receptors in the brain. Some small studies and anecdotal reports suggest mood-stabilizing effects, but these data are neither robust nor specific to irritability.

In summary, valerian’s use for supporting or treating irritability is primarily justified by traditional use, with only indirect or weak scientific evidence. There is a need for well-designed clinical trials to evaluate its efficacy for this specific indication.

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Products containing Valerian

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