Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus acidophilus for Irritable Bowel Syndrome (IBS): Evidence Review

Lactobacillus acidophilus is a probiotic bacterium commonly found in the human gut and in various fermented foods. Its use in supporting or treating IBS is based on the premise that probiotics may help restore gut microbiota balance, reduce inflammation, and modulate immune function—all factors implicated in IBS pathophysiology.

Several randomized controlled trials (RCTs) and meta-analyses have evaluated the efficacy of L. acidophilus either alone or as part of multi-strain probiotic supplements in IBS patients. Some studies show modest benefits, such as reduced abdominal pain, bloating, and improved stool consistency. However, results are inconsistent: some trials found no significant difference compared to placebo, while others noted only slight improvements.

A 2020 meta-analysis (Didari et al., World J Gastroenterol) concluded that while certain strains of Lactobacillus (including L. acidophilus) may improve global IBS symptoms, the overall effect size is small, and the quality of evidence is moderate to low. Guidelines from groups like the American College of Gastroenterology suggest that probiotics may help some IBS patients, but do not specifically endorse L. acidophilus alone due to variability in strains and formulations studied.

In summary, the use of L. acidophilus for IBS has some scientific support, but the evidence is not robust or consistent. Its benefit appears modest at best, so its use is typically considered as an adjunct rather than a primary therapy.

More about Lactobacillus acidophilus
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