Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus gasseri is a probiotic bacterium that has been studied for its potential benefits in managing Irritable Bowel Syndrome (IBS). The use of L. gasseri is justified by emerging scientific evidence, although this evidence is still limited and not yet conclusive. Several small clinical trials have investigated the effects of L. gasseri on IBS symptoms, with some studies reporting improvements in abdominal pain, bloating, and stool consistency. For instance, a 2012 double-blind, placebo-controlled study found that supplementation with L. gasseri OLL2716 reduced symptoms in patients with IBS, particularly abdominal pain and discomfort.

The rationale for its use is based on the ability of L. gasseri to modulate the gut microbiota, enhance intestinal barrier function, and reduce gut inflammation—factors believed to play a role in IBS pathophysiology. Additionally, L. gasseri’s production of lactic acid may help inhibit pathogenic bacteria and support a healthy gut environment. However, the overall quality of evidence is modest, with relatively few high-quality, large-scale randomized controlled trials. Most studies have small sample sizes and varying methodologies, which limits the generalizability of their findings.

In summary, while there is some scientific evidence supporting the use of Lactobacillus gasseri for IBS, more rigorous research is needed before it can be widely recommended. Current guidelines suggest that probiotics may help some people with IBS, but they do not single out L. gasseri as uniquely effective.

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