Plectranthus amboinicus, commonly known as Indian borage or Cuban oregano, has a long history of use in traditional medicine systems in Asia, Africa, and the Caribbean. Traditionally, the plant’s leaves are used to treat a variety of gastrointestinal complaints, including indigestion, flatulence, and abdominal pain, which overlap in symptomatology with Irritable Bowel Syndrome (IBS). Folk remedies often involve the consumption of leaf extracts, teas, or decoctions for stomach upset and digestive disorders.

Despite its widespread use in folk medicine, direct scientific evidence supporting the efficacy of Plectranthus amboinicus specifically for IBS is limited. Preclinical studies have demonstrated that the plant possesses anti-inflammatory, antimicrobial, and antispasmodic properties, which could theoretically address certain aspects of IBS, such as intestinal spasms or dysbiosis. However, these studies are primarily in vitro or in animal models and do not specifically address IBS as defined in clinical practice. There are currently no well-designed clinical trials evaluating its safety or efficacy in IBS patients.

In summary, the use of Plectranthus amboinicus for IBS is primarily rooted in traditional medicine, with some biological plausibility based on its pharmacological properties. However, the overall evidence rating remains low due to the lack of direct clinical validation.