Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a natural polyphenolic compound found in grapes, berries, and peanuts, has attracted attention for its anti-inflammatory and antioxidant properties. Its use in the context of Irritable Bowel Syndrome (IBS) is supported by a small but growing body of scientific research primarily from animal studies and a few clinical trials. Several preclinical studies have shown that resveratrol can modulate gut inflammation, oxidative stress, and intestinal barrier function—factors believed to play a role in IBS pathophysiology. For example, resveratrol has been observed to reduce visceral hypersensitivity and improve gut motility in animal models.

The human data are limited but promising. A notable randomized, double-blind, placebo-controlled clinical trial published in 2016 (Zamani et al., Gastroenterology Research and Practice) found that supplementation with 150 mg/day of resveratrol for 6 weeks significantly improved IBS symptoms and quality of life compared to placebo. The proposed mechanisms include downregulation of pro-inflammatory cytokines and improvement of oxidative status.

However, the evidence is still preliminary with only a few small-scale clinical trials, and larger, more rigorous studies are needed to confirm efficacy and establish optimal dosing and safety. While resveratrol is not a traditional remedy for IBS, its emerging scientific rationale places it in the category of a novel supplement with modest but not definitive clinical support for IBS symptom management.

More about resveratrol
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Other ingredients used for Irritable Bowel Syndrome

Other health conditions supported by resveratrol

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