Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has garnered scientific interest as a potential adjunct in the management of Irritable Bowel Syndrome (IBS), largely due to its immunomodulatory effects and its role in gut barrier function. Several observational studies have reported a higher prevalence of vitamin D deficiency among individuals with IBS compared to healthy controls. A few small-scale randomized controlled trials (RCTs) have explored whether vitamin D supplementation improves IBS symptoms, with mixed results. Some studies have found that supplementation leads to a reduction in symptom severity and improvement in quality of life, while others have not observed significant benefits.

The proposed mechanisms include vitamin D’s ability to modulate immune responses, reduce inflammation, and influence gut microbiota composition. Additionally, vitamin D receptors are expressed throughout the gastrointestinal tract, suggesting a potential direct effect on intestinal function.

However, the overall quality and size of existing studies are limited. Meta-analyses and systematic reviews generally conclude that there is some evidence for benefit but that the evidence is not robust or consistent enough to recommend routine use of vitamin D specifically for IBS symptom management in the absence of an underlying deficiency. As a result, while there is scientific rationale and preliminary data supporting its use, the evidence is currently modest (rating 2/5), and vitamin D supplementation for IBS should be considered on an individual basis, particularly in those with confirmed deficiency.

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Other ingredients used for Irritable Bowel Syndrome

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