Barleria species, especially Barleria prionitis, have been traditionally used in Ayurvedic and other folk medicine systems for managing skin ailments, including itching (pruritus). The leaves and extracts are commonly applied externally in the form of pastes or poultices to relieve itching, inflammation, and skin irritation. These uses are well-documented in traditional medicinal texts and ethnobotanical surveys from India and Southeast Asia.

The rationale for such traditional use is largely based on the observed anti-inflammatory and soothing effects of Barleria preparations. While some preliminary pharmacological studies have reported that Barleria extracts possess anti-inflammatory and antimicrobial properties, direct scientific studies specifically targeting pruritus or the mechanisms of itch relief are limited. Most evidence remains anecdotal or based on traditional practice rather than robust clinical trials.

In summary, the use of Barleria for itching is justified primarily by traditional knowledge and practices. Although some related pharmacological activities have been identified, scientific validation for its effectiveness in treating itching specifically is minimal, and more research is needed to confirm its efficacy and safety for this indication.