Davilla rugosa, a plant native to Brazil and other parts of South America, has been traditionally used in folk medicine for a variety of skin conditions, including pruritus (itching). Ethnobotanical surveys and regional pharmacopeias document its use among local populations as a remedy for skin irritation, wounds, and itching, often as topical preparations from its leaves or extracts. However, the scientific validation for its antipruritic (anti-itch) effects is extremely limited. While some studies have explored the plant's broader pharmacological properties—such as anti-inflammatory, antioxidant, and antimicrobial activities—there is little direct clinical or preclinical evidence to confirm its effectiveness specifically for treating itching in humans or animals. The primary support for its use against itching remains anecdotal and rooted in traditional practices rather than in rigorously controlled scientific studies. Therefore, while Davilla rugosa is used for itching in some traditional medical systems, the evidence supporting this application is weak, with almost all references relying on ethnobotanical records rather than experimental data.