The use of Elephant's Head (Pedicularis spp.) to support or treat itching is primarily based on traditional medicine practices rather than robust scientific evidence. In various traditional systems, especially in regions where the plant is native (such as parts of Asia, Europe, and North America), Elephant's Head has been used for its purported anti-inflammatory and skin-soothing properties. Folk remedies sometimes involve applying preparations of the plant topically to alleviate skin irritation, itching, or minor wounds. However, the exact rationale for its use in itching appears to be anecdotal, passed down through generations in local herbal medicine traditions.

There is a lack of modern clinical research or pharmacological studies directly evaluating the efficacy or safety of Elephant's Head for itching. The plant does contain certain iridoids and flavonoids, which in other contexts have shown anti-inflammatory properties, but there is no direct evidence linking these compounds to relief from pruritus (itching) in humans. Thus, while its use is documented in traditional herbal lore, there is minimal to no scientific validation, and the quality of traditional evidence is limited.