Jessica's Sticktight, more commonly known as Bidens pilosa or Spanish Needle, has a history of traditional use in various cultures for managing skin conditions, including itching (pruritus). Ethnobotanical records from regions in Africa, Asia, and the Americas document the topical application of preparations made from the leaves or aerial parts of the plant for relief from minor skin irritations, rashes, and itching. This use is largely based on folk knowledge and the plant’s perceived soothing and anti-inflammatory properties. However, the scientific literature offers minimal direct clinical evidence supporting its efficacy specifically for itching. Most studies involving Bidens pilosa focus on its anti-inflammatory, antimicrobial, and antioxidant properties in vitro or in animal models, rather than on controlled trials in humans for pruritus. Thus, while its use for itching is supported by traditional medicine practices, the lack of rigorous scientific validation and controlled clinical data limits the strength of evidence. The rating of 1 reflects the reliance on tradition with only indirect support from modern pharmacological studies.