The use of the Matapalo tree (commonly referring to species in the Ficus or Clusia genera, often known as "strangler figs") for treating itching is primarily rooted in traditional medicine, particularly among indigenous communities in Central and South America. Historical ethnobotanical records indicate that extracts from the bark, leaves, or latex of Matapalo have been applied topically to alleviate skin irritations, rashes, and itching. The practices are typically passed down orally or documented in local herbal pharmacopeias, with the latex or decoctions sometimes being used for their purported anti-inflammatory or soothing properties.

However, there is a notable scarcity of rigorous scientific studies directly evaluating the efficacy or safety of Matapalo preparations for pruritus (itching). Most available sources are anecdotal or based on ethnomedical surveys rather than controlled clinical trials. While some preliminary research on related Ficus species suggests the presence of bioactive compounds with potential anti-inflammatory or antimicrobial properties, there is no direct evidence confirming these effects translate to relief from itching in humans.

In summary, the use of Matapalo tree for itching is justified by traditional knowledge rather than scientific validation. The evidence base is limited and rates as 2 out of 5, reflecting anecdotal and historical use but a lack of robust clinical data.