Evidence supporting the use of: Urea
For the health condition: Itching Ears

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Urea is a keratolytic agent commonly used in dermatology to soften and dissolve the horny layer (stratum corneum) of the skin. Its use in treating itching ears (pruritus auris) is based on its ability to hydrate and break down dry, thickened, or scaly skin, which can contribute to itching. Several clinical guidelines and reviews reference the use of urea-containing ear drops for conditions such as chronic otitis externa or dry, flaky ear canals, where pruritus is a symptom. Limited small-scale studies and case reports suggest that urea can improve symptoms by reducing scaling and promoting moisture balance in the external auditory canal. However, robust randomized controlled trials specifically focused on urea for itching ears are lacking. Most evidence is extrapolated from its broader dermatological applications and from clinical experience rather than high-quality, condition-specific research. Urea is considered safe for topical use in the external ear as long as the tympanic membrane is intact. It is sometimes found in combination ear preparations alongside other emollients or mild antiseptics. Overall, while its use is scientifically plausible and supported by some clinical practice, the strength of direct evidence is moderate to low.

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Products containing Urea

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