Evidence supporting the use of: Allantoin
For the health condition: Itching (rectal)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Allantoin is a compound commonly used in topical formulations for its skin-soothing, moisturizing, and keratolytic properties. Its use in the management of rectal itching (pruritus ani) is justified by its well-established role in promoting skin healing and reducing irritation. The scientific evidence supporting its use for rectal itching is modest but present, largely based on its inclusion in over-the-counter (OTC) hemorrhoidal and anti-pruritic preparations.

Some clinical guidelines and reviews mention allantoin as a safe and non-sensitizing agent that can help alleviate symptoms associated with minor skin irritations, including those in the anal area. Its mechanism of action involves promoting cell proliferation and wound healing, as well as softening keratin, which can help restore the skin barrier and reduce itch.

However, there are few high-quality, placebo-controlled trials specifically evaluating allantoin for rectal itching. Most evidence comes from its historical use, in vitro studies, and its presence in combination products (often with ingredients like witch hazel or hydrocortisone). Regulatory agencies such as the FDA recognize allantoin as a skin protectant for minor skin irritations, which supports its OTC use.

In summary, while direct scientific evidence is limited (hence the rating of 2), allantoin’s documented skin-protectant and soothing effects provide a reasonable basis for its inclusion in products aimed at relieving rectal itching.

More about Allantoin
More about Itching (rectal)

Products containing Allantoin

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