Sapindus mukorossi, commonly known as soapnut or reetha, is a plant with a long history of use in traditional Ayurvedic medicine. Its fruits contain saponins, which exhibit natural cleansing, antimicrobial, and anti-inflammatory properties. In traditional Indian medicine, Sapindus mukorossi has been used externally for various skin conditions, including itching and irritation. There are anecdotal reports and some older Ayurvedic texts that recommend topical application of its extracts to relieve itching, including in sensitive areas such as the rectum, particularly for conditions like hemorrhoids or pruritus ani. The rationale is based on its supposed soothing, cleansing, and antimicrobial effects.

However, there is a lack of high-quality scientific studies or clinical trials directly evaluating the efficacy or safety of Sapindus mukorossi for rectal itching. The evidence is largely historical and based on empirical use in traditional systems. Some laboratory studies have demonstrated antimicrobial activity for Sapindus extracts, but these are not specific to rectal applications or pruritus ani. There are also no mainstream medical guidelines recommending its use for this purpose.

In summary, while traditional usage exists for Sapindus mukorossi in the management of itching, including rectal itching, scientific validation is minimal, and the evidence should be regarded as weak and primarily rooted in historical practice.