Blepharis, particularly species such as Blepharis edulis and Blepharis maderaspatensis, has a history of use in traditional medicine systems like Ayurveda and Unani for managing liver ailments, including jaundice. Ethnobotanical surveys and traditional medicinal texts from regions such as India and North Africa mention the use of Blepharis preparations for symptoms related to liver dysfunction, often as part of polyherbal formulations. However, the supporting evidence for its efficacy in treating jaundice is primarily anecdotal or based on practitioner experience, rather than on controlled scientific studies.

In terms of modern research, there is a scarcity of well-designed pharmacological or clinical studies evaluating Blepharis species for hepatoprotective effects or specific activity against jaundice in adults. Some in vitro and animal studies suggest that Blepharis extracts may have antioxidant or mild anti-inflammatory properties, which could theoretically be beneficial in liver health. Nonetheless, these findings are preliminary and do not directly establish effectiveness for jaundice. No robust clinical trials or systematic reviews exist to validate its use for this indication.

In summary, Blepharis is used for jaundice primarily based on traditional knowledge, with minimal scientific validation to support its use for this purpose in adults.