Evidence supporting the use of: Didymocarpus
For the health condition: Jaundice (adults)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Didymocarpus, particularly Didymocarpus pedicellata, has a long-standing history of use in traditional Ayurvedic and folk medicine, especially in the Indian subcontinent, for supporting liver health and treating conditions such as jaundice. Traditional practitioners have employed extracts or powders from the leaves and stems of the plant, often in polyherbal formulations, to support liver function and alleviate symptoms related to jaundice, such as yellowing of the skin and eyes, fatigue, and digestive discomfort. These uses are documented in several ethnobotanical surveys and traditional medical texts, where Didymocarpus is listed among hepatoprotective herbs. However, the scientific evidence supporting the efficacy of Didymocarpus for jaundice is limited. A small number of preclinical studies suggest antioxidant and mild hepatoprotective effects of Didymocarpus extracts, but these studies are preliminary, often in animal models, and do not specifically address jaundice in humans. No high-quality clinical trials have been published to date that validate its use for treating jaundice in adults. Most of the support for Didymocarpus in jaundice management remains anecdotal or based on traditional knowledge rather than robust scientific validation. In summary, Didymocarpus is used to support jaundice primarily due to traditional practices, with only weak or indirect scientific evidence available, warranting further research to ascertain its efficacy and safety for this indication.

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