Plectranthus amboinicus (commonly known as Indian borage or Cuban oregano) has a long history of use in various traditional medicine systems, particularly in South Asia and Africa, for a range of ailments including respiratory conditions, digestive issues, and liver-related disorders. Its use for jaundice in adults is primarily documented in ethnobotanical and folk medicine sources. In traditions such as Ayurveda and certain regional practices, decoctions or infusions of the leaves are sometimes given to individuals with jaundice, with the belief that the plant may support liver function and help clear bilirubin.

However, scientific research specifically evaluating Plectranthus amboinicus for the treatment or support of jaundice is very limited. A few preclinical studies have shown that extracts from the plant may have hepatoprotective properties in animal models, indicating a possible benefit for liver health. These studies usually assess markers of liver damage or oxidative stress rather than clinical jaundice itself, and there are no robust clinical trials in humans that confirm efficacy or safety for this use. Therefore, the evidence is largely traditional, supported by anecdotal reports and preliminary laboratory data rather than rigorous scientific validation.

In summary, while Plectranthus amboinicus is traditionally used to support liver health and sometimes for jaundice, there is insufficient scientific evidence to substantiate its effectiveness for this specific condition in adults.