Evidence supporting the use of: Three-Leaf-Caper
For the health condition: Jaundice (adults)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Three-Leaf Caper (Crateva religiosa or Crateva adansonii) has a long-standing place in traditional medicine, particularly within Ayurvedic and other South Asian healing systems, where it is used to support liver health and treat conditions such as jaundice in adults. Historical texts and ethnobotanical reports frequently mention its use for “Kamala” (jaundice) and other hepatic disorders. The bark and leaves are most commonly used, often prepared as decoctions or powders. The rationale in traditional systems is based on the herb’s reputed ability to stimulate liver function, promote bile flow, and aid in the detoxification process. While there are a limited number of preclinical studies indicating hepatoprotective activities of Crateva religiosa extracts in animal models (such as protection against chemically-induced liver injury), robust clinical evidence in humans is lacking. The few available studies are either preliminary or involve small sample sizes, and none provide definitive proof of efficacy for jaundice in adults. As such, the use of Three-Leaf Caper for jaundice is justified mostly by traditional use rather than modern scientific validation. The evidence rating is moderate (2/5), reflecting traditional use with some supportive, but not conclusive, preclinical data. More rigorous clinical studies are required to establish efficacy and safety for this indication in humans.

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