Evidence supporting the use of: Polygodial
For the health condition: Jock Itch
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Polygodial is a sesquiterpenoid dialdehyde derived from plants such as Polygonum hydropiper and Tasmannia lanceolata. Its use in supporting or treating jock itch (tinea cruris), a fungal infection of the groin, is based primarily on its demonstrated antifungal properties in laboratory studies. Several in vitro studies have shown that polygodial exhibits antifungal activity against dermatophytes, including species of Trichophyton and Epidermophyton, which are common causative agents of jock itch. The proposed mechanism involves disruption of fungal cell membranes, leading to cell death.
Despite these promising laboratory findings, there is a lack of robust clinical evidence supporting the efficacy of polygodial in treating human fungal infections such as jock itch. Most available data come from in vitro experiments or animal models, and there are no well-designed human clinical trials confirming its effectiveness or safety for this specific condition. Nevertheless, the scientific rationale for its use is stronger than mere traditional use, as polygodial's antifungal actions are well documented at the preclinical level. Therefore, while polygodial appears to have potential as an antifungal agent, more research—including controlled clinical studies—is needed to substantiate its use for treating jock itch in humans.
Other health conditions supported by Polygodial
Athlete's FootFungal Infections
Insect Repellant
Jock Itch
Parasites (general)
Parasites (nematodes, worms)
Wounds and Sores