Cissus sicyoides, commonly known as "princess vine" or "grape ivy," has a long history of use in traditional medicine in various regions, particularly in parts of the Caribbean and Central and South America. Traditionally, preparations made from the leaves and stems of Cissus sicyoides have been used to address multiple health concerns, including joint pain, inflammation, and rheumatism. The rationale behind its use for supporting the joints is largely based on ethnobotanical practices, where it is believed to possess anti-inflammatory and analgesic properties that could alleviate symptoms associated with joint disorders.

While there are several reports of traditional use, scientific research specifically validating the efficacy of Cissus sicyoides for joint health is limited. Some in vitro and animal studies on the broader Cissus genus (notably Cissus quadrangularis) suggest potential anti-inflammatory and antioxidant effects, but these findings cannot be directly extrapolated to Cissus sicyoides due to differences in phytochemical composition. Human clinical trials focused on Cissus sicyoides for joint support or arthritis are lacking.

In summary, the use of Cissus sicyoides for joint health is primarily justified by traditional practices rather than robust scientific evidence. Until more focused research is conducted, its role in supporting the joints should be regarded as traditional and anecdotal.