Evidence supporting the use of: Flavonoids
For the body system: Joints
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Flavonoids are a diverse group of phytonutrients found in many fruits, vegetables, and plants. Their use to support joint health is primarily based on scientific evidence, though much of it is preclinical or from small-scale human studies. Flavonoids have demonstrated anti-inflammatory and antioxidant properties, which are relevant to joint health, as joint disorders like osteoarthritis and rheumatoid arthritis involve inflammation and oxidative stress.
Studies have shown that certain flavonoids—such as quercetin, rutin, and epigallocatechin gallate (EGCG)—can reduce the production of pro-inflammatory cytokines and enzymes involved in cartilage degradation. In animal models, supplementation with flavonoids has resulted in reduced joint inflammation, decreased cartilage destruction, and improved symptoms of arthritis. Some small human trials suggest potential benefits in reducing pain and improving function in people with osteoarthritis, but results are inconsistent and not all flavonoids have been studied equally.
Overall, while there is scientific rationale and some encouraging research supporting the use of flavonoids for joint health, the evidence is not yet robust or conclusive. Larger, high-quality clinical trials are needed to confirm their effectiveness and determine optimal dosages and specific flavonoid compounds. Until then, flavonoids can be considered a promising but not definitively proven option for supporting joint health.
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alfalfaalgal oil
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beta caryophyllene
black cumin
black currant
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borage oil
boron
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bovine
bovine gelatin
broccoli
bromelain
burdock
cabbage leaf
calamari oil
cartilage
cat's claw
cherry
Chinese salvia root
chondroitin
cissus quadrangularis
collagen
turmeric
curcumin
cuspidatum root
devil's claw
dog rose
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fish oil
fish protein
flavonols
flaxseed
gamma linolenic acid (GLA)
gelatin
ginger
glucosamine
gokhru
gooseberry
gotu kola
green lipped mussel
guggul
horsetail
hyaluronic acid
Indian tinospora
knotweed
krill oil
l-proline
mackerel
manganese
marine lipid
methylsulfonylmethane (MSM)
microcrystalline hydroxyapatite concentrate (MCHC)
milk
moringa
mustard seed
n-acetyl-glucosamine
nettle
olive
omega-3 fatty acids
omega-6 fatty acids
phellodendron amurense
phytocannabinoids
pine bark
pineapple
plantain
protein
quercetin
rehmannia glutinosa
rhizome
rose hips
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sardines
scrophularia root
serratiopeptidase
silicon
black ginger
specialized pro-resolving mediators (SPMs)
triphala
vitamin C
vitamin D
seaweed
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white willow
wild yam
sarsaparilla
red clover
boneset
chickweed
gastrodia
capsicum
clerodendrum indicum
hedychium spicatum
punarnava
commiphora
paederia foetida
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tinospora cordifolia
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queen of the meadow
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anemarrhena asphodeloides
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barrenwort
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camphor oil
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noni
herbal blend (proprietary)
algae
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gravel root
bladderwrack
arnica
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Antler
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Asteracea
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Amor seco
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Bidens pilosa
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Boswellia
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Bee products
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bovine cartilage / glycosaminoglycan
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Bee venom
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Boerhavia diffusa
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Chinese Silkvine
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Cinnamomum
Chinese Mountain Ant
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Cod Liver Oil
Coriander
Clerodendrum phlomidis
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Cyathula
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Capsaicin
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Curcumen
Cymbopogon Martini
Centella asiatica
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Cissus sicyoides
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Elephant Vine
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Elk antler
Emu Oil
Eicosapentaenoic Acid
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