Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glucosamine Hydrochloride is commonly used as a dietary supplement to support the joints, with the intention of alleviating symptoms of osteoarthritis, particularly knee osteoarthritis. The scientific evidence for its effectiveness, however, is mixed and generally regarded as limited. Several randomized controlled trials and meta-analyses have investigated glucosamine (both hydrochloride and sulfate forms), but the majority of robust clinical trials suggest that glucosamine hydrochloride provides little to no clinically significant benefit compared to placebo in reducing joint pain or improving function.

The most consistent findings come from large, well-conducted studies such as the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT), which found no significant benefit of glucosamine hydrochloride over placebo for knee osteoarthritis pain. Some smaller studies and reviews suggest modest effects, but these are often not statistically significant or are subject to bias. It is important to note that glucosamine sulfate (a different salt form) has been studied more extensively and may have somewhat better—though still modest—evidence for benefit.

Overall, while glucosamine hydrochloride is widely used and generally considered safe, its scientific support for joint health is weak. Most major guidelines, including those from the American College of Rheumatology and the Osteoarthritis Research Society International, do not recommend glucosamine hydrochloride for routine management of joint pain due to insufficient evidence of efficacy.

More about Glucosamine Hydrochloride
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Other body systems supported by Glucosamine Hydrochloride

Joints
Structural System

Products containing Glucosamine Hydrochloride

We currently have no products on Vitabase that contain this ingredient.