Evidence supporting the use of: Glycosaminoglycans
For the body system: Joints

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Glycosaminoglycans (GAGs), such as chondroitin sulfate and hyaluronic acid, are natural components of connective tissue, including cartilage, synovial fluid, and the extracellular matrix in joints. Their use in joint health is supported by a substantial body of scientific evidence, especially regarding chondroitin sulfate and hyaluronic acid. Clinical trials and meta-analyses suggest that oral supplementation with chondroitin sulfate can modestly reduce pain and improve function in individuals with osteoarthritis, particularly of the knee. Hyaluronic acid, often administered via intra-articular injection, is also shown to benefit joint lubrication and reduce symptoms in some osteoarthritis patients. The mechanisms include attracting and retaining water in cartilage, contributing to shock absorption, and modulating inflammatory processes in the joint microenvironment. While not all studies report significant benefits, and effect sizes are generally moderate, the overall body of evidence supports the use of certain GAGs as adjuncts to standard care in joint health. However, efficacy can vary depending on the specific type of GAG, dosage, formulation, and patient population. Thus, while not a replacement for disease-modifying therapies, glycosaminoglycans have a justified, evidence-based role in supporting joint structure and function, particularly in osteoarthritis management.

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Products containing Glycosaminoglycans

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