Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Manganese is an essential trace mineral involved in various physiological processes, including bone development and maintenance of connective tissues. Scientifically, manganese functions as a cofactor for several enzymes, such as glycosyltransferases, which are important in the formation of cartilage and bone matrix. Deficiency in manganese has been shown, primarily in animal studies, to result in skeletal deformities and impaired joint function. In humans, outright deficiency is rare, but observational data suggest that manganese supports normal bone metabolism and collagen formation, which are relevant to joint health. However, there is limited direct evidence from randomized controlled trials or large-scale human studies specifically demonstrating that manganese supplementation improves joint health or reduces symptoms of joint disorders (such as osteoarthritis) in the general population. Most of the scientific support is indirect—based on manganese's biochemical roles and findings from deficiency models. As a result, while the theoretical rationale is sound and supported by basic science, clinical validation in joint disease or supplementation contexts is modest. Therefore, manganese is often included in joint health supplements, but its direct benefit in supporting joint health in well-nourished individuals remains to be clearly established.

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Other ingredients that support Joints

Other body systems supported by manganese

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