Evidence supporting the use of: Mangiferin
For the body system: Joints

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mangiferin is a polyphenolic compound found primarily in mangoes (Mangifera indica) and has been studied for its potential health benefits, including effects on joint health. The justification for its use in supporting the joints body system is primarily based on preclinical research. Several animal and in vitro studies have shown that mangiferin exhibits anti-inflammatory, antioxidant, and cartilage-protective properties. These activities are relevant to joint health, particularly in conditions such as osteoarthritis and rheumatoid arthritis, where inflammation and oxidative stress contribute to joint degradation.

For example, studies in rodent models of arthritis have demonstrated that mangiferin can reduce levels of pro-inflammatory cytokines (such as TNF-α and IL-1β), inhibit enzymes involved in cartilage breakdown (like MMPs), and decrease overall joint swelling and damage. Its antioxidant properties may also help limit oxidative damage in joint tissues. However, as of mid-2024, there is a lack of robust clinical trial data in humans directly supporting mangiferin supplementation for joint health. Most evidence comes from laboratory and animal studies, with only preliminary or indirect human data available.

In summary, the use of mangiferin for joint support is supported by a moderate amount of preclinical scientific evidence, but clinical validation in humans is limited. More rigorous trials are needed to confirm its efficacy and safety for joint health in humans.

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Products containing Mangiferin

We currently have no products on Vitabase that contain this ingredient.