Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Methylsulfonylmethane (MSM) is an organosulfur compound commonly used as a dietary supplement for joint health. Scientific evidence suggests that MSM may provide modest benefits for individuals with osteoarthritis and joint pain. Several randomized, double-blind, placebo-controlled clinical trials have been conducted, with some showing statistically significant reductions in pain and improvements in physical function. For example, a study published in Osteoarthritis and Cartilage (2006) found that participants with knee osteoarthritis who took 3 grams of MSM twice daily for 12 weeks experienced significant improvements in pain and physical function compared to placebo.

The proposed mechanisms include MSM's anti-inflammatory and antioxidant properties, which may help reduce joint degeneration and pain. However, while initial results are promising, systematic reviews and meta-analyses generally conclude that the overall quality of evidence is moderate, with some studies showing benefit and others showing minimal or no effect. The differences in study design, dosages, and outcome measures make it difficult to draw definitive conclusions about MSM’s efficacy. Safety profiles are generally good, with few reported adverse effects at typical dosages.

In summary, MSM is used to support the joint system based on a moderate body of scientific evidence. While not all studies agree, there is enough clinical research to justify its use for joint comfort and osteoarthritis symptom relief, though effects are likely to be modest.

More about Methylsulfonylmethane
More about Joints

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Other body systems supported by Methylsulfonylmethane

Immune System
Joints
Muscles
Skin

Products containing Methylsulfonylmethane

We currently have no products on Vitabase that contain this ingredient.