Paeoniflorin is a major bioactive compound found in the root of Paeonia lactiflora, commonly known as peony. In traditional Chinese medicine (TCM), peony root has been used for centuries to support joint health, particularly in formulations aimed at alleviating symptoms of rheumatic and arthritic conditions. Classical TCM texts describe its use for "dispelling wind and dampness," which are metaphors commonly associated with joint discomfort, stiffness, and inflammation.

Modern pharmacological studies have identified anti-inflammatory and immunomodulatory effects of paeoniflorin in cell and animal models. For instance, paeoniflorin has been shown to inhibit pro-inflammatory cytokines and reduce joint swelling in experimental arthritis models. However, clinical studies in humans remain limited. Some small-scale or preliminary trials suggest potential benefit, but robust, high-quality clinical evidence is lacking. Thus, while traditional use is well documented and supported by some preclinical data, there is insufficient scientific validation at this time to rate its efficacy highly for joint health in humans.

In summary, paeoniflorin's use for joint support is justified by historical tradition and some supporting laboratory research, but comprehensive human studies are still needed to establish clear scientific efficacy.