Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that has gained attention for its potential in supporting joint health, particularly due to its anti-inflammatory and analgesic properties. Several preclinical and clinical studies have examined PEA's effects on chronic pain and inflammation, including in conditions that affect the joints such as osteoarthritis. PEA is believed to exert its effects primarily by modulating mast cell behavior and reducing the production of pro-inflammatory mediators. It also interacts with the endocannabinoid system, which plays a role in pain regulation.

Clinical studies, though generally small in scale, have reported that PEA supplementation may reduce pain and improve function in people with osteoarthritis and other chronic pain conditions. For instance, a 2013 randomized controlled trial showed that PEA supplementation over 8 weeks significantly reduced pain scores in patients with knee osteoarthritis compared to placebo. However, while results are promising, the overall quality of evidence is limited by small sample sizes and short study durations. Major clinical guidelines for joint health or osteoarthritis do not currently include PEA as a standard therapy, underscoring the need for larger, more rigorous studies.

In summary, there is scientific evidence, albeit moderate in strength, supporting PEA's use for joint support, particularly in reducing pain and inflammation. More robust clinical trials are needed to confirm its efficacy and safety for long-term use in joint disorders.

More about Palmitoylethanolamide (PEA)
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Other body systems supported by Palmitoylethanolamide (PEA)

Brain
Gastrointestinal Tract
Immune System
Joints
Nerves
Respiratory System

Products containing Palmitoylethanolamide (PEA)

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