Evidence supporting the use of: Polyphenols (unspecified)
For the body system: Joints

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyphenols are a diverse group of naturally occurring compounds found in plants, with well-documented antioxidant and anti-inflammatory properties. Scientific interest in polyphenols—such as those found in green tea (EGCG), curcumin (from turmeric), and resveratrol (from grapes)—has led to research on their potential role in supporting joint health, particularly in conditions like osteoarthritis and rheumatoid arthritis. Several preclinical and clinical studies suggest that polyphenols can modulate inflammatory pathways, reduce oxidative stress, and potentially inhibit cartilage degradation, all of which are mechanisms relevant to joint health.

For example, curcumin has been shown in randomized controlled trials to reduce symptoms of joint pain and inflammation in osteoarthritis patients, sometimes with efficacy comparable to nonsteroidal anti-inflammatory drugs (NSAIDs), though often at higher doses. Similarly, green tea polyphenols have demonstrated anti-inflammatory effects in animal models and some small human trials. However, while these results are promising, the evidence tends to be ingredient-specific, and the effects can vary depending on dosage, bioavailability, and formulation. There is a lack of large-scale, long-term clinical trials involving generic "polyphenols" as a category for joint support, leading to moderate overall evidence (3/5). In summary, there is scientific support for the use of certain polyphenols in joint health, but more robust studies are needed to generalize these findings across all polyphenols.

More about Polyphenols (unspecified)
More about Joints

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Products containing Polyphenols (unspecified)

We currently have no products on Vitabase that contain this ingredient.