Proteolytic enzymes, also known as proteases, are a group of enzymes that break down proteins into smaller peptides or amino acids. Common examples include bromelain (from pineapple), papain (from papaya), and animal-derived enzymes such as trypsin and chymotrypsin. Their use for joint support is justified by a moderate body of scientific evidence, particularly in the context of inflammation and pain reduction in joint conditions such as osteoarthritis and rheumatoid arthritis.

Several clinical studies have assessed the effects of proteolytic enzyme supplementation on joint health. Bromelain and combinations of proteases have demonstrated anti-inflammatory properties, reducing swelling, pain, and stiffness in some patients with arthritis or sports injuries. Some trials have reported efficacy comparable to nonsteroidal anti-inflammatory drugs (NSAIDs), though results are variable and often limited by small sample sizes and heterogeneous study designs.

The proposed mechanisms include modulation of prostaglandin pathways, reduction of inflammatory cytokines, and fibrinolytic activity, which may contribute to improved joint comfort and function. However, systematic reviews and meta-analyses generally conclude that while there are promising findings, the overall quality of evidence is moderate due to methodological limitations and potential publication bias.

In summary, there is some scientific validation for the use of proteolytic enzymes in supporting joint health, especially for symptomatic relief of pain and inflammation, but more rigorous large-scale studies are needed to confirm their efficacy and safety.