Evidence supporting the use of: Withanolides
For the body system: Joints

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Withanolides are naturally occurring steroidal lactones found primarily in the plant Withania somnifera (Ashwagandha). The use of Ashwagandha, and by extension withanolides, for joint health primarily stems from traditional Ayurvedic medicine, where the herb has been used for centuries as a "Rasayana" or rejuvenating tonic. Historically, it has been prescribed for conditions characterized by joint pain and inflammation, such as arthritis. The rationale in traditional systems is based on Ashwagandha’s reputed anti-inflammatory and strengthening properties.

Modern scientific studies directly evaluating withanolides for joint health are limited. Some preclinical animal and in vitro studies suggest anti-inflammatory effects of withanolides, including inhibition of pro-inflammatory cytokines. However, robust clinical trials in humans specifically addressing joint health outcomes such as pain, function, or disease progression are lacking. Most available evidence comes from broader studies on Ashwagandha extracts, not purified withanolides, and often focuses on inflammation rather than direct assessment of joint disease.

In summary, the use of withanolides for supporting joint health is primarily justified by traditional use, with only preliminary scientific support. Clinical effectiveness in joint-related conditions remains to be fully established.

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Products containing Withanolides

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