Homalomena, a genus of tropical plants widely used in traditional medicine across Southeast Asia, is primarily employed in folk remedies for a range of ailments, including kidney-related conditions. Historical ethnobotanical surveys and traditional Chinese medicine texts cite the use of Homalomena species—such as Homalomena aromatica—for their purported anti-inflammatory and diuretic effects, which are believed to help in alleviating symptoms of urinary tract infections and supporting kidney function. However, these traditional uses are largely based on empirical observation and cultural transmission rather than systematic clinical evidence.

Scientific validation for the use of Homalomena in treating kidney infections is extremely limited. There are a few phytochemical studies indicating that extracts from Homalomena species contain various bioactive compounds (e.g., flavonoids, essential oils) with general antimicrobial and anti-inflammatory properties, but these studies do not specifically address kidney infections or provide robust clinical data. No controlled human trials or comprehensive pharmacological studies have been published to directly support its efficacy for kidney infections. Thus, while the traditional use is documented, scientific evidence remains weak, justifying a low evidence rating.