Indian Chrysanthemum (Chrysanthemum indicum) has been used in traditional Indian and Chinese medicine for a variety of ailments, including fevers, headaches, and inflammatory conditions. In the context of kidney infections, its use is primarily justified by traditional practices, particularly within systems like Ayurveda and Traditional Chinese Medicine (TCM). These traditions sometimes employ Chrysanthemum indicum as part of herbal formulas intended to "clear heat" or "detoxify" the body, which may loosely correspond to infections or inflammatory states, including those affecting the kidneys.

However, there is minimal direct scientific evidence supporting the use of Indian Chrysanthemum specifically for kidney infections (pyelonephritis). Some laboratory studies have demonstrated that extracts of Chrysanthemum indicum possess anti-inflammatory, antioxidant, and mild antimicrobial properties, but these findings are general and not specific to kidney infection pathogens or clinical settings. There are no robust clinical trials or pharmacological studies confirming efficacy or safety for treating kidney infections in humans. Therefore, the evidence is limited to traditional usage, and the scientific validation remains weak.