Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Gravel root (Eupatorium purpureum), also known as "Joe-Pye weed," has a long history of use in traditional herbal medicine for urinary tract issues, including kidney stones. Historically, Native American and early European herbalists used gravel root as a diuretic ("water pill") and to purportedly "break down" or "expel" urinary stones—hence the common name "gravel root." Its use was based on empirical observation rather than rigorous scientific study, and it was often prepared as a tea or tincture. The root was included in several 19th- and early 20th-century herbal pharmacopeias for kidney and bladder complaints.

However, modern scientific validation is lacking. There are very few, if any, well-controlled clinical studies evaluating gravel root's efficacy in treating or preventing kidney stones. Some laboratory studies have identified compounds such as euparin and other alkaloids that may have mild diuretic or anti-inflammatory effects, but there is no direct evidence that these compounds dissolve stones or significantly impact kidney stone formation or passage in humans. Additionally, gravel root contains pyrrolizidine alkaloids, which may be toxic to the liver if consumed in large amounts or over prolonged periods.

In summary, gravel root's use for kidney stones is primarily supported by tradition and historical practices, with minimal to no scientific evidence confirming its effectiveness or safety for this condition.

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