The use of fruit blends to support kidney health is primarily rooted in traditional and folk medicine rather than robust scientific validation. Many cultures have historically recommended fruits such as cranberries, blueberries, pomegranates, and watermelon for supporting urinary tract and kidney function. The rationale is often based on the hydration provided by fruits with high water content and their natural antioxidant compounds, which are believed to help reduce oxidative stress in the kidneys. For example, cranberries have a long-standing reputation in folklore for supporting urinary tract health, which is sometimes extrapolated to kidney health. Watermelon is commonly used in traditional Chinese medicine to "cool" the body and support renal function.

However, scientific studies specifically evaluating proprietary fruit blends for direct kidney support are limited. Some individual fruits, such as cranberries, have moderate evidence supporting their role in preventing urinary tract infections, but this does not necessarily extend to kidney health or function. General fruit consumption is associated with overall health due to vitamin, mineral, and antioxidant content, and some epidemiological studies suggest a diet rich in fruits may be beneficial for kidney health as part of a healthy lifestyle. Nevertheless, there is no strong clinical evidence that proprietary fruit blends specifically target or improve kidney function beyond these general benefits.