Heal-All (Prunella vulgaris) has a long history of use in traditional herbal medicine across Europe, Asia, and North America. In these traditions, Heal-All has been valued for its purported "cooling" and "detoxifying" properties, and it has occasionally been employed as a supportive herb for the urinary tract and kidneys. Traditional Chinese Medicine, for example, has used Prunella vulgaris in formulas for "clearing heat" and relieving swelling, which may be interpreted as supporting the excretory system, including the kidneys. Western herbal traditions sometimes reference its use as a diuretic or to support urinary tract health, which is tangentially related to kidney function.

Despite this traditional use, there is very limited scientific evidence specifically linking Heal-All to kidney health or direct support of the renal system. Published pharmacological studies have focused more on its anti-inflammatory, antioxidant, antimicrobial, and wound-healing activities, rather than its effects on kidney function. No robust clinical trials or animal studies directly supporting the use of Prunella vulgaris for kidney health have been identified in the scientific literature as of 2024. Therefore, the justification for its use in supporting the kidneys is primarily traditional, and the overall strength of evidence is low.