Operculina turpethum (commonly known as Indian Jalap or Trivrit) has a long history of use in traditional Ayurvedic medicine, where it is described as a powerful purgative and is sometimes included in herbal formulations aimed at supporting the urinary and kidney systems. In Ayurvedic texts, Trivrit is believed to help clear "Ama" (toxins) and is used in "Virechana" (purgation therapy), which is occasionally prescribed for disorders attributed to impaired kidney function or fluid retention.

However, direct evidence of its benefit specifically for kidney health is limited to these traditional uses and theories. There are very few, if any, modern scientific studies investigating its effects on renal physiology or its efficacy in supporting healthy kidney function in humans. Most available pharmacological research on Operculina turpethum focuses on its laxative, anti-inflammatory, and hepatoprotective effects rather than direct renoprotective actions.

In summary, while there is a traditional basis for using Operculina turpethum as part of protocols that may support detoxification and, by extension, the kidneys, strong scientific evidence for its direct renal benefits is lacking. Its use in this context remains primarily justified by traditional practices rather than robust clinical data.