Polygonatum (commonly known as Solomon’s Seal) has a long history of use in Traditional Chinese Medicine (TCM) and other Asian herbal traditions for supporting the kidneys and overall vitality. In TCM, several species of Polygonatum (notably Polygonatum sibiricum and Polygonatum multiflorum) are classified as "yin tonic" herbs, believed to nourish kidney yin, replenish bodily fluids, and support the lower back and knees—symptoms often associated with kidney deficiency in TCM theory. This traditional use is well-documented in classical texts and remains common in contemporary herbal practice in East Asia.

However, scientific validation for Polygonatum’s specific efficacy on the kidneys in humans is limited. Some laboratory and animal studies suggest antioxidant, anti-inflammatory, and protective effects on renal tissue, but these findings are preliminary and not directly translatable to clinical outcomes in humans. Most published research focuses on general health effects, such as immune modulation, anti-diabetic properties, or neuroprotection, rather than kidney-specific benefits. To date, there is no robust clinical evidence from controlled human trials confirming that Polygonatum supports kidney function in a manner recognized by modern biomedicine.

In summary, while historical and traditional use for kidney support is strong and well-documented in herbal medicine, scientific evidence is still developing and not sufficient to firmly validate these claims.