Evidence supporting the use of: Vitamin D
For the body system: Kidneys

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin D is scientifically validated as an important nutrient for kidney health, particularly in the context of chronic kidney disease (CKD). The kidneys play a vital role in converting vitamin D to its active form, calcitriol (1,25-dihydroxyvitamin D), which is critical for calcium and phosphate balance in the body. In CKD, the kidneys lose this ability, leading to vitamin D deficiency and disturbances in mineral metabolism, which can cause bone disease (renal osteodystrophy) and increase the risk of cardiovascular complications.

Multiple clinical guidelines, including those from Kidney Disease: Improving Global Outcomes (KDIGO), recommend monitoring and managing vitamin D status in patients with kidney disease. Supplementing with vitamin D or its active analogs can help correct secondary hyperparathyroidism, improve bone health, and may have additional benefits such as reducing proteinuria and inflammation in CKD patients, although data regarding these outcomes are still being investigated.

It is important to note that vitamin D supplementation for kidney health is primarily relevant for individuals with impaired kidney function or those at risk of deficiency. For people with healthy kidneys, routine supplementation is not specifically targeted for kidney support. Overall, the connection between vitamin D and kidney health is robust, with a strong scientific basis, especially in the context of CKD management.

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