Evidence supporting the use of: Vitamin D (mixed)
For the body system: Kidneys

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin D is supported by scientific evidence for its role in kidney health, particularly in relation to calcium and phosphate regulation. The kidneys are crucial for converting inactive vitamin D (cholecalciferol or ergocalciferol) into its active form, calcitriol (1,25-dihydroxyvitamin D). This active form is essential for maintaining calcium and phosphate balance, which is vital for bone health and other metabolic processes. In chronic kidney disease (CKD), the kidneys lose their ability to activate vitamin D, often leading to deficiencies that contribute to secondary hyperparathyroidism, bone disease, and disturbances in mineral metabolism.

Supplementation with vitamin D or its analogs is a standard part of managing CKD-related mineral and bone disorders. Numerous clinical guidelines, including those from the Kidney Disease: Improving Global Outcomes (KDIGO) organization, recommend vitamin D supplementation for patients with CKD and vitamin D deficiency. Randomized controlled trials and observational studies support the use of vitamin D to manage mineral bone disease and reduce parathyroid hormone (PTH) levels in CKD. However, while vitamin D can address deficiencies and certain complications of kidney disease, it does not directly improve kidney function or reverse kidney disease.

In summary, there is strong scientific evidence for the use of vitamin D to support the metabolic functions of the kidney, particularly in the context of CKD. The evidence rating is not the highest (5) because benefits are limited to specific conditions rather than general kidney support, and excessive vitamin D can carry risks in renal impairment.

More about Vitamin D (mixed)
More about Kidneys

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Products containing Vitamin D (mixed)

We currently have no products on Vitabase that contain this ingredient.