False Unicorn Root (Chamaelirium luteum) has a long history of use in traditional North American herbal medicine, particularly among Indigenous peoples and 19th-century eclectic physicians, as a remedy to support female reproductive health, including labor and delivery. Historically, it was believed to "tone" the uterus and support the reproductive system, and thus was included in herbal formulas intended to prepare women for childbirth or to address issues like threatened miscarriage or weak uterine contractions. Despite this traditional use, there is a lack of robust modern scientific evidence to validate these claims. No high-quality clinical trials or pharmacological studies have demonstrated its safety or efficacy for labor and delivery. Most modern references to its use are based on historical texts, anecdotal reports, or traditional herbal compendia rather than contemporary research. Additionally, improper identification and overharvesting of the plant have made it less available and raised conservation concerns. In summary, the use of False Unicorn Root for labor and delivery is rooted in tradition rather than scientific validation, and current evidence to support its effectiveness is extremely limited.