Evidence supporting the use of: Bacillus coagulans
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacillus coagulans is a spore-forming probiotic bacterium that has been studied for its effects on gut health, including conditions associated with increased intestinal permeability, commonly referred to as "Leaky Gut Syndrome." The scientific evidence specifically supporting B. coagulans for leaky gut is limited but growing. Some animal studies suggest that supplementation with B. coagulans can improve intestinal barrier function, reduce inflammation, and modulate gut microbiota. For example, studies in rodents have shown that B. coagulans can upregulate tight junction proteins and decrease endotoxemia induced by gut barrier dysfunction. There are also a few small human studies where B. coagulans supplementation led to improvements in symptoms associated with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), conditions that may involve altered gut permeability, though these trials rarely measured gut permeability directly.

Despite this, direct clinical trials assessing the effect of B. coagulans on gut permeability in humans are sparse. The rationale for its use is primarily extrapolated from its general probiotic effects—modulating inflammation, balancing gut microbiota, and supporting gut barrier integrity. While promising, the currently available evidence does not rise above a modest level (rated 2/5) due to a lack of large, well-controlled, direct studies in humans with leaky gut. Thus, the use of Bacillus coagulans for leaky gut is scientifically plausible but not conclusively validated.

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