Evidence supporting the use of: Bifidobacterium (mixed)
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bifidobacterium (mixed species) is supported by some scientific evidence for use in managing aspects of "Leaky Gut Syndrome," a term commonly used to describe increased intestinal permeability. While "Leaky Gut Syndrome" is not a formally recognized medical diagnosis, increased intestinal permeability is measurable and implicated in several gastrointestinal and systemic diseases. Multiple studies have shown that certain Bifidobacterium species can enhance tight junction integrity and reduce intestinal permeability in both animal models and humans. For example, Bifidobacterium infantis and Bifidobacterium longum have demonstrated the ability to modulate the gut barrier, decrease pro-inflammatory cytokines, and support mucosal health. Clinical trials in patients with irritable bowel syndrome, inflammatory bowel disease, and other related conditions have reported improvements in gut symptoms and biomarkers of permeability after supplementation with Bifidobacterium-containing probiotics. However, direct clinical evidence for the use of Bifidobacterium specifically for "Leaky Gut Syndrome" in otherwise healthy adults is limited, and most studies focus on related conditions with documented barrier dysfunction. Overall, the use of Bifidobacterium is scientifically plausible and partially validated for supporting gut barrier function, but higher-quality and more targeted research is needed to firmly establish efficacy for "Leaky Gut Syndrome" as popularly defined.

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